Dosage guide · 10 mg vial

Mazdutide Dosage Protocol

IBI362 / LY3305677 · dual GLP-1 and glucagon receptor agonist

Published GLORY-1 escalation was once weekly: 2 mg in weeks 1–4, 4 mg in weeks 5–8, then 6 mg. With 1 mL in a 10 mg vial, the mix is 10 mg/mL, so the 2 mg starting amount is 20 units (0.2 mL) on a U-100 syringe.

How oftenOnce weekly

Starting dose2 mg

Start = units20 units

Mix1 mL BAC water

Reviewed 25 Oct 2026 · Education only, not medical advice

Mazdutide 10 mg vial

Not currently stocked by Peak Peptides Australia

No product photo — this strength isn't stocked by Peak

Dosage chart How to mix Supplies Calculator About Mazdutide References

01 · DOSAGE CHART

Mazdutide dosage chart

Published weekly escalation · 10 mg vial + 1 mL BAC water

BAC water added

Concentration10 mg/mL

1 unit (U-100)100 mcg= 0.01 mL

How oftenOnce weeklySubcutaneous injection

1 mL is the default calculator mix because it makes the 2 mg, 4 mg and 6 mg chart amounts 20, 40 and 60 units.

Mazdutide dosage chart for a 10 mg vial mixed with 1 mL of bacteriostatic water
Week	Weekly dose	Syringe units
Weeks 1–4Start	2 mg	20 units0.2 mL
Weeks 5–8	4 mg	40 units0.4 mL
Week 9 onwardsMaintenance	6 mg	60 units0.6 mL

Once weekly · subcutaneous injection

The published schedule steps up after 4 weeks at each lower amount.

The chart stops at 6 mg, the highest amount in this published escalation.

This chart reproduces a published clinical-trial escalation; mazdutide has no TGA or US FDA approval. Education only, not medical advice. Dose amounts adapted from GLORY-1 published 6 mg dose-escalation schedule (Ji et al., New England Journal of Medicine, 2025); units are recalculated for the vial and mix selected above.

02 · HOW TO MIX

Mixing a 10 mg vial with 1 mL of BAC water

Using a 1 mL (100-unit) insulin syringe, one full draw of bacteriostatic water gives 10 mg/mL.

1
Add the water slowly
Wipe both rubber stoppers with an alcohol swab and let them dry. Draw 1 mL of bacteriostatic water and let it run slowly down the inside of the vial wall — not straight onto the powder.
2
Swirl gently
Swirl or roll the vial gently until the powder has dissolved. Give it a few minutes to settle if needed.
3
Don't shake it
Shaking can damage the peptide and cause foaming. Gentle swirling only.
4
Check it's fully clear
Only use it once it is fully clear with no particles. Label the vial with the date and 10 mg/mL, then store it in the fridge at 2–8 °C.

Full illustrated reconstitution guide

03 · SUPPLIES NEEDED

What you'll need

Counts follow the dosage chart above at the highest amount in each step, using a 10 mg vial mixed with 1 mL.

Length of protocol

3Mazdutide 10 mg vials24 mg needed in total

111 mL insulin syringesU-100, 27–31G · one per draw + one per vial mixed

1BAC water 10 mL bottle3 mL used for mixing

22Alcohol swabsSkin + stopper, every time

Plus an approved sharps container. Syringes and swabs are sold by Australian pharmacies — Peak Peptides and Pure Performance supply the bacteriostatic water.

Peak Peptides Australia Bacteriostatic water 10 mL

Bacteriostatic water 10 mLPeak Peptides Australia

Pure Performance Australia Bacteriostatic water 10 mL

Bacteriostatic water 10 mLPure Performance Australia

04 · CALCULATOR

Check a different amount

Enter your vial, water and dose to see the matching syringe units.

Concentration Calculator

Labelled Vial Amount (mg)

Verified Final Liquid Volume1 mL

Amount to Evaluate (not a recommendation)

Concentration

10.00 mg/mL

(10000 mcg/mL)

Calculated Liquid Volume

0.200 mL

Equivalent U-100 volume scale position

20markings (not biological IU)

Illustration of a U-100 volume scale, not preparation or injection guidance

05 · PROTOCOL DETAILS

About Mazdutide

Protocol overview

Starting dose: 2 mg once weekly for weeks 1–4
How it increases: 4 mg in weeks 5–8, then 6 mg from week 9
Frequency: Once weekly, subcutaneously
Highest charted amount: 6 mg once weekly
Common calculator mix: 1 mL water in 10 mg → 10 mg/mL

Storage

Before mixing: Follow the exact vial label; GLORY-1 does not establish storage conditions for independently supplied vials.
After mixing: Refrigerate at 2–8 °C and protect from light; this is generic reconstituted-vial handling, not a validated mazdutide expiry.
Never: Use a vial after its supplier's validated use-by date, or if the solution is cloudy or has particles.

How it works

Mazdutide, also called IBI362 or LY3305677, is an oxyntomodulin analogue that activates both the GLP-1 receptor and the glucagon receptor. It is given once weekly in the published obesity research program.

GLP-1 receptor activity is associated with glucose-dependent insulin release, slower gastric emptying and appetite-related effects. Glucagon receptor activity may affect hepatic energy metabolism and energy expenditure; the combined mechanism is being investigated in clinical research.

Illustrated mechanism explainer

What the research shows

GLORY-1 randomly assigned 610 Chinese adults with obesity or overweight to 4 mg mazdutide, 6 mg mazdutide or placebo for 48 weeks, followed by 12 weeks off treatment.
In the 6 mg GLORY-1 group, the published escalation was 2 mg weekly for weeks 1–4, 4 mg for weeks 5–8, then 6 mg for weeks 9–48.
At week 48, mean body-weight change was −11.00% with 4 mg, −14.01% with 6 mg and 0.30% with placebo in the treatment-policy analysis.
A 24-week phase 2 trial randomised 248 Chinese adults; mean body-weight change was −11.3% with 6 mg mazdutide and 1.0% with placebo.
Mazdutide, branded Xinermei, received its first approval in China in June 2025 for long-term weight management. It is not approved by the TGA or US FDA; DailyMed's mazdutide search returned zero US label records.

Reported side effects

In GLORY-1, the most frequently reported adverse events were gastrointestinal and were mostly mild to moderate; trial-regimen discontinuation occurred in 0.5% of the 6 mg group, 1.5% of the 4 mg group and 1.0% of the placebo group.
In the 24-week phase 2 trial, gastrointestinal events appeared dose-related and were most common during escalation. At 6 mg, nausea occurred in 41.0%, diarrhoea in 31.1% and vomiting in 27.9% of participants.
In that phase 2 trial, hypoglycaemia with plasma glucose at or below 3.9 mmol/L occurred in 3.3% of the 6 mg group and no severe hypoglycaemia was reported.

Important notes

Mazdutide is approved in China as Xinermei for specified indications, but it is not approved for human use in Australia or the United States.
The chart copies a protocol-controlled clinical-trial schedule. It cannot establish the identity, purity, sterility, stability or suitability of an independently supplied vial.
GLP-1 receptor agonist labels carry warnings about pancreatitis, gallbladder disease and rodent thyroid C-cell tumours. Mazdutide has no US FDA label, so these class warnings do not replace product-specific safety data.
WADA's 2026 Prohibited List does not name mazdutide; WADA advises athletes to check with their anti-doping organisation when a substance is not found on the list.
Never use a mixed vial that is cloudy or has particles in it.

Injection basics

Use a new sterile 1 mL (100-unit) U-100 insulin syringe, 27–31G, every time — never reuse or share.
Wipe the vial stopper and the skin with an alcohol swab and let both dry first.
Inject under the skin (subcutaneously) of the abdomen, thigh or upper arm, and rotate sites.
Put used syringes straight into an approved sharps container — the NDSS lists Australian disposal options.

Guidance: World Health Organization · National Diabetes Services Scheme (NDSS)

06 · QUICK ANSWERS

Mazdutide questions

How many units is each Mazdutide amount in a 10 mg vial?

With 1 mL in a 10 mg vial, the concentration is 10 mg/mL. The 2 mg, 4 mg and 6 mg amounts are 20 units (0.2 mL), 40 units (0.4 mL) and 60 units (0.6 mL) on a U-100 syringe.

How much bacteriostatic water is used for Mazdutide 10 mg?

This calculator's default is 1 mL for a 10 mg/mL concentration. At that concentration, 10 units is 1 mg and 20 units is 2 mg. The selector also shows 1.5 mL and 2 mL options.

How long does a 10 mg Mazdutide vial last?

By mass alone, a 10 mg vial contains five 2 mg weekly amounts. At 4 mg it contains two full amounts with 2 mg remaining; at 6 mg it contains one full amount with 4 mg remaining. This arithmetic does not establish a validated mixed-vial expiry.

What is 1 mg in the default Mazdutide mix?

With 10 mg in 1 mL, 1 mg is 0.1 mL, which is 10 units on a U-100 syringe.

07 · SOURCES